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• Z. Johnson, A.E.I. Proudfoot and T.M. Handel. "Interaction of Chemokines and Glycosaminoglycans: A New Twist in the Regulation of Chemokine Function with Opportunities for Therapeutic Intervention." Cyokines and Growth Factor Reviews. 2005 (in press)
• P. Housmand, T.M. Handel, A. Zlotnik. "The Role of Chemokines in Tumor Development and Metastasis." 2005 (submitted book chapter)
• D. Huang, J. Wujek, G. Kidd, T. He, A. Cardona, M. Sasse, E. Stein, J. Kish, M. Tani, A.E. Proudfoot, B.J. Rollins, T.M. Handel, R.M. Ransohoff "Chronic Expression of Monocyte Chemoattractant Protein-1 in the Central Nervous System Causes Delayed Encephalopathy and Impaired Migroglial Function in Mice. " The Faseb Journal. 2005 (accepted)
• T.M. Handel, Z. Johnson, S.E. Crown, M. Sweeney, A.E. Proudfoot. "Regulation of Chemokine Function by Glycosaminoglycans - As Exemplified by Chemokines." Annual Review of Biochemistry. 2005 74:385-410.
• R. Sandhoff, H. Grieshaber; R. Djafarzadeh, T.P. Sijmonsma, A.E.I. Proudfoot, T.M. Handel, H. Wiegandt, H. Wiegandt, P.J. Nelson. "Chemokines Bind to Sulfatides as Revealed by Surface Plasmon Resonance." 2005. Biochim Biophys Acta 1687:52-63.
• N. Pokala and T.M. Handel. "Energy Functions for Protein Design II: Adjustment with Protein Complex Affinities, Reference States, and Properties of Designed Sequences." J Mol Biol. 2005 347:203-27.
• N. Pokala and T.M. Handel. "Energy Functions for Protein Design I: Efficient and Accurate Continuum Electrostatics and Solvation." Protein Science. 2004 13:925-36.
• E.K. Lau, A. Hsu, S. Allens and T.M. Handel. "Chemokine-Receptor Interactions: GPCRs, Glycosaminoglycans and Viral Chemokine Binding Proteins." Advances in Protein Chemistry. 2004 88:351-91.
• T.M. Handel and E.K. Lau. "Chemokine Structure and Receptor Interactions." Book Chapter in Ernst Shering Research Foundation Workshop Series. 2003 45:101-124.
• B.T. Seet, C.A. McCaughan, T.M. Handel, G. McFadden and S. B. Fleming. "Identification and Analysis of a Chemokine Binding Protein from the Orf Poxvirus." PNAS. 2003 100:15137-42.
• A.E.I. Proudfoot, T.M. Handel, Z. Johnson, E.K. Lau, P. Liwang, I. Clark-Lewis, F. Borlat, T.N.C. Wells and M. Kosco-Vilbois. "Glycosaminoglycan Binding and Oligomerization are Essential for the In Vivo Activity of Certain Chemokines. " PNAS. 2003 100:1885-90.
• J.M. Alexander, C.A. Nelson, V. van Berkel Fezzie, E.K. Lau, J.M. Studts, T.J. Brett, S.H. Speck, T.M. Handel, H.W. Virgin and D.H. Fremont. "Structural Basis of Chemokine Sequestration by a Herpesvirus Decoy Receptor." Cell. 2002 111:343-56.
• J.C. Lougheed, P.J. Domaille and T.M. Handel. "Solution Structure and Dynamics of the Melanoma Inhibitory Activity Protein (MIA)." Journal of Biomolecular NMR. 2002 22:211-23.
• T.M. Handel, Carolyn Bertozzi, and Jeff Hubbell. "Biopolymer Engineering and Design: Beyond the Genome." Current Opinion in Chemical Biology. 2001 5:675-676.
• B.T. Seet, R. Singh, C. Paavola, E.K. Lau, T.M. Handel and G. McFadden. "Molecular Determinants for CC Chemokine Recognition by a Poxvirus CC-Chemokine Inhibitor." PNAS. 2001 98:9008-13.
• Pokala N and Handel TM. "Review: protein design--where we were, where we are, where we're going." Journal of Structural Biology. 2001 134:269-81.
• J.C. Lougheed, J.M. Holton, T. Alber, J.F. Bazan, and T.M. Handel. "Structure Of Melanoma Inhibitory Activity Protein (MIA), A Member Of A New Family Of Secreted Proteins." PNAS. 2001 98:5515-20.
• L.S. Mizoue, T.N. Kledal, K.B. Bacon, T.M. Handel. "Recognition Of The CX3C Chemokine, Fractalkine, By Its Cognate Receptor And The Viral Receptor US28." J. of Biol Chem. 2001 276:33906-14.
• L.A. Marcaurelle, J. Wilken, L.S. Mizoue, L. Oldham, T.M. Handel and C.R. Bertozzi. "Chemical Synthesis of Lymphotactin, a GlycosylatedChemokine with a C-Terminal Mucin-like Domain." Chemistry: A European Journal. 2001 7:1129-1132.
• D.A. Hoover, L. Mizoue, T.M. Handel and J. Lubkowski. "The Crystal Structure Of The Chemokine Domain Of Fractalkine Shows A Novel Quaternary Arrangement." Journal of Biological Chemistry. 2000 275:23187-23193.
• A.K. Chamberlain, K.M. Fisher, D. Reardon, T.M. Handel and S. Marqusee. "Folding of an Isolated Ribonuclease H Core Fragment." Protein Science. 1999 8:2251-2257.
• G.A. Lazar, E.C. Johnson, J.R. Desjarlais and T.M. Handel. "Rotamer Strain as a Determinant of Protein Specificity." Protein Science. 1999 8:2598-2610.
• E.C. Johnson and T.M. Handel. "The Effect of Hydrophobic Core Packing on Side Chain Dynamics." Journal of Biomolecular NMR. 1999 15:135-143.
• S. Hemmerich, C. Paavola, A. Bloom, S. Bhakta, R. Freedman, D. Grunberger, J. Krstenansky, S. Lee, D. McCarley, M. Mulkins, B. Wong, J. Pease, L. Mizoue, I. Polsky, K. Thompson, T.M. Handel, K. Jarnagin. "Identification of Residues in the Monocyte Chemotactic Protein-1 that Contact the MCP-1 Receptor, CCR2b." Biochemistry. 1999 38:13013-13025.
• K. Jarnagin, D. Grunberger, M. Mulkins, B.Wong, S. Hemmerich, C. Paavola, A.Bloom, S. Bhakta, R. Freedman, D. McCarley, I. Polsky, A. Ping-Tsou, A. Kosaka, T.M. Handel. "Identification of Surface Residues of the Monocyte Chemotactic Protein-1 that Affect Signaling through the MCP-1 Receptor, CCR2b." Biochemistry. 1999 38:16167-16177.
• E.C. Johnson, G.A. Lazar, J.R. Desjarlais and T.M. Handel. "Solution Structure and Dynamics of a Designed Hydrophobic Core Variant of Ubiquitin." Structure with Folding and Design. 1999 7:967-76.
• J.R. Desjarlais and T.M. Handel. "Hydrophobic Core Design and Structure Prediction with Backbone Flexibility." Journal of Molecular Biology. 1999 289:305-318.
• L. Mizoue, J.F. Bazan, E.C. Johnson and T.M. Handel. "Solution Structure and Dynamics of the CX3C Chemokine Domain of Fractalkine and its Interaction with an N-terminal Fragment of CX3CR1." Biochemistry. 1999 38:1402-1414.
• J.W. Bryson, J.R. Desjarlais, T.M. Handel, TM and W.F. DeGrado. "From Coiled Coils To Small Globular Proteins: Design of a Native-Like Three-Helix Bundle." Protein Science. 1998 7:1404-1414.
• G.A. Lazar and T.M. Handel. "Hydrophobic Core Packing and Protein Design." Current Opinion in Chemical Biology. 1998 2:675-679.
• C. Paavola, S. Hemmerich, D. Grunberger, I. Polsky, A. Bloom, R. Freedman, M. Mulkins, S. Bhakta, D. McCarley, L. Wiesent, B. Wong, K. Jarnagin, T.M. Handel. "Monomeric Monocyte Chemoattractant Protein-1 (MCP-1) Binds and Activates the MCP-1 Receptor CCR2b." Journal of Biological Chemistry. 1998 273:33157-33165.
• G. Kern, T.M. Handel and S. Marqusee. "Characterization of a Folding Intermediate from HIV-1 RNase H." Protein Science. 1998 7:2164-2174.
• J. Hedrick, V. Saylor, D. Figueroa, L. Mizoue, Y. Xu, S. Menon, J. Abrams, T.M. Handel, and A. Zlotnick. "Lymphotactin is Produced by NK Cells and Attracts both NK and T Cells in vitro." Journal of Immunology. 1997 158:1533-1540.
• J. Davis, D. Agard, T.M. Handel and V. Basus. "Alterations in Chemical Shifts and Exchange Broadening Upon Peptide Boronic Acid Inhibitor Binding to alpha-lytic Protease." Journal Biomolecular NMR. 1997 10:21-27.
• G. Lazar, JR Desjarlais, T.M. Handel. "De Novo Design of the Hydrophobic Core of Ubiquitin." Protein Science. 1997 6:1167-1178.
• J. Lubkowski, G. Bujacz, L. Boque, P.J. Domaille, T.M. Handel and A. Wlodawer. "Structure of MCP-1 in Two Crystal Forms: A Rare Example of Variable Quaternary Interactions." Nature Structural Biology. 1997 4:64-9.
• A.K. Chamberlain, T.M. Handel, and S. Marqusee. "Detection of Rare Partially Folded Molecules in Equilibrium with the Native Conformation of RNASE H." Nature Structural Biology. 1996 3:782-7.
• T.M. Handel and P.J. Domaille. "Heteronuclear (1H, 13C, 15N) NMR Assignments and Solution Structure of the Monocyte Chemotactic Protein-1 (MCP-1) Dimer." Protein Science. 1996 35:6569-6584.
• J.R. Desjarlais and T.M. Handel. "De novo Design of the Hydrophobic Cores of Proteins." Protein Science. 1995 4:2006-2018.
• J.R. Desjarlais and T.M. Handel. "Principles of Protein Design." Current Opinions in Biotechnology. 1995 6:460-466.